Age at diagnosis of patients with non-HFE and HFE-related HH. The age at diagnosis is shown for patients with HJV-, HAMP-, TFR2-, and HFE-related HH. Patients with HFE HH have been divided into probands and nonprobands. Graphs show individual data points, and box and whisker plots show median value, upper and lower quartiles, and range. Variables were compared using 1-way analysis of variance and Tukey’s multiple comparison test. Statistically significant differences are denoted as (a) compared with HJV, (b) compared with HAMP, (c) compared with TFR2, and (d) compared with HFE proband.