miR-17-92 enhances T- and B-cell pathogenicity in BO. B10.BR mice were conditioned with total-body irradiation and Cytoxan (120 mg/kg) and transferred with either 1 × 10⁷ TCD-BM from WT or miR-17-92^flox/floxCD19Cre⁺ B6 mice, or plus 0.65 × 10⁵ T cells from WT or miR-17-92^flox/floxCD4Cre⁺ B6 mice. (A-C) Pulmonary resistance, elastance, and compliance are shown at 60 days after BMT (N = 5-12 mice per group). (D-E) Collagen deposition in lung was evaluated by Masson Trichrome stain (original magnification ×200) and quantified by measuring the blue area by ImageJ software. (F-I) Mean percentage of PD-1^hiCXCR5⁺ Tfh (on gated H2K^b+ CD4⁺Foxp3⁻ cells), ratio of Tfr to Tfh cells (ratio of Foxp3⁺ to Foxp3⁻ cells gated on H2K^b+CD4⁺PD-1^hiCXCR5⁺ cells), GC B cells (GL-7⁺Fas⁺ on gated H2K^b+B220⁺ cells), and plasma cells (B220^lowCD138⁺ on gated H2K^b+cells) in recipient spleen are shown at 60 days after BMT. *P < .05; **P < .01; ***P < .001.