Tyrosine kinase fusion genes identified in JMML. (A-C) Structure of detected fusion proteins. (A) RANBP2-ALK, identified in UPN168; (B) DCTN1-ALK, identified in UPN5; (C) TBL1XR1-ROS1, identified in UPN106. aa, amino acid; F-box like, F-box like domain; FN TypeIII, fibronectin type III domain; LDL-R, low-density lipoprotein receptor class A domain; LisH, Lis homology domain; MAM, MAM domain; RanBD1, Ran binding domain 1; TK, tyrosine kinase domain; TM, transmembrane domain; TPR, tetratricopeptide repeat domain.