Genome-wide occupancy of RUNX1 in CD34⁺cells derived from iPSCs determined by ChIP-Seq. (A) Venn diagram showing overlap of RUNX1 target genes in RUNX1 mutation-corrected CD34⁺ cells and BC1 iPSC-CD34⁺ cells. (B) Visual inspection of gene loci showed RUNX1 binding to known target genes in RUNX1 mutation-corrected CD34⁺ cells and BC1 iPSC-CD34⁺ cells: RUNX1, SPI1, and HHEX. (C) Pie chart showing the distribution of RUNX1 binding peaks in RUNX1 mutation-corrected CD34⁺ cells. (D) De novo motif discovery of sequences bound by RUNX1 in RUNX1 mutation-corrected CD34⁺ cells is consistent with the known RUNX1 motif. (E) GO enrichment analysis of RUNX1 binding genes in RUNX1 mutation-corrected CD34⁺ cells. 5′ UTR, 5′ untranslated region.