(A) FISH for MYC using MYC break-apart probe in DLBCL. (B) In the study of Scott et al, GCB, ABC, and unclassified DLBCLs represent 50%, 38%, and 12% of all DLBCLs, respectively. MYC-R DLBCL (yellow) accounts for 17.7% of GCB, 6.5% of ABC, and 5% of unclassified DLBCLs. (C) MYC-R was detected in 12.2% of cases with DLBCL morphology, including 5.3% of DLBCLs with MYC sole rearrangement; 4.2% of MYC/BCL2 HGBL-DH; 1.2% of MYC/BCL6 HGBL-DH; and 1.7% of MYC/BCL2/BCL6 HGBL-TH. Overall, HGBL-DH/TH represents ∼8% of cases with DLBCL morphology.