Schematic representation of the glycolytic and glutaminolytic pathways in an FLT3-ITD⁺ AML cell under normal conditions (left), with FLT3 inhibition (middle), and with FLT3 and glutamine inhibition (right). FLT3 inhibition reduces glycolysis without equally affecting glutamine metabolism or glutathione (GSH) production; thus, combination FLT3/glutamine inhibition synergizes to increases apoptosis in FLT3-ITD cells. P, phospho; ROS, reactive oxygen species; shRNA, short hairpin RNA. See the complete Figure 6 in the article by Gallipoli et al that begins on page 1639.