An EFS and OS for patients with or without clonal IGH rearrangements. Kaplan-Meier estimates of EFS (A) and OS (B) for patients from both risk groups combined who did not have a dominant clonal IGH rearrangement by HTS. A subset of 67 patients had no IGH rearrangements and had a worse prognosis than those in whom IGH rearrangements were detected (P = .0110). There was no discernible difference in OS for these patients.