P4HA2 improves B lymphoma depending on Carabin. Knockdown of Carabin abolishes the inhibition of B-lymphoma cell growth by suppression of P4HA2. SU-DHL-4 (A), SU-DHL-6 (B), and NU-DUL-1 (C) cells transduced with P4HA2 shP2 or NC control were induced to express Carabin shC or NC control. Then, a cell growth assay was performed. Points, mean (n = 6); bar, SD; *P < .05; ***P < .001. Knockdown of Carabin abolishes the inhibition of Erk1/2 kinase activity by suppression of P4HA2. SU-DHL-4 (D), SU-DHL-6 (E), and NU-DUL-1 (F) cells were stimulated with PMA (40 ng/mL) for 30 minutes (+) or not (−), and then analyzed by immunoblotting for the indicated proteins. (G-I) P4HA2 promotes B-lymphoma cell proliferation in vivo depending on Carabin. The resected tumors (G) from individual nude mice. The tumor volume (H) of the xenografts. Points, mean (n = 7); bar, SD; *P < .01; ***P < .001. The tumor weight (I) of the xenografts after dissection. Scatter plot, mean (n = 7); bars, SD; ***P < .001.