Lymphoma B-cell crosstalk with a recipient cell in the WM BM is mediated by MVs or exosomes carrying the MyD88^265P complex (myddosome). In the parent B cell, the mutated MyD88 protein activates the NF-κB pathway inducing proinflammatory cytokine and immunoglobulin M (IgM) release. MyD88^265P is also packaged into exosomes or is enclosed into MVs budding off the surface of the parent cell. These vesicles transport it to recipient cells such as mast cells or macrophages in the BME. Once taken up into the cytoplasm, the MyD88^265P complex recruits endogenous MyD88^wt, activates the NF-κB pathway, and reprograms the recipient cell to produce proinflammatory cytokines. See Figure 6 in the article by Manček-Keber et al that begins on page 1720.