Pharmacokinetics of ADCT-402 in rat and cynomolgus monkey. (A) Quantitation of total antibody and PBD-conjugated ADCT-402 in rat serum from 3 individual Crl:CD (SD) rats treated with a single IV dose of 1.5 mg/kg. (B) Quantitation of total antibody, PBD-conjugated antibody, and free PBD dimer warhead SG3199 in cynomolgus monkey serum after IV administration of 0.6 mg/kg ADCT-402 on days 1 and 22. The results are mean ± SEM (n = 2/5 male and 2/5 female).