Protein desialylation as a clear-me sign in platelets. Over the platelet lifespan, surface glycoproteins lose the terminal sialic acid residues in their glycans, a process associated with clearance. Neuraminidases are glycoside hydrolases that can remove terminal sialic acid from glycans. Neuraminidases are found in platelets, which present neuraminidase on their surface downstream of GPIb-IX complex signaling. In many glycans, desialylation leads to exposure of the penultimate galactose residues on glycans. These can in turn be recognized by the AMR. Further deglycosylation leads to exposed GlcNAc residues, which may be recognized by other carbohydrate receptors and potentially mediate their uptake by macrophages.