Figure 7.
Thrombin generation and fibrin network in hemophilia. (A) TF-induced (1 pM) thrombin generation in PRP from F8−/−Pros1+/+ and F8−/−Pros1−/− mice depicting TFPI-dependent PS activity. (B) APC-dependent PS activity in PRP and PFP from F8−/−Pros1+/+ and F8−/−Pros1−/− mice. (C) Representative scanning electron microscopy images from F8+/+Pros1+/+, F8−/−Pros1+/+, and F8−/−Pros1−/− fibrin structure and from F9+/+Pros1+/+, F9−/−Pros1+/+, and F9−/−Pros1−/− fibrin structure (Scale bars: 1 μm). (D-G) Thrombin generation triggered by low TF concentration (1 pM) in PFP (D-E) and PRP (F-G) from severe HA patients (FVIII < 1%) without (D,F) and with (E,G) a high titer of inhibitor. Measurements are presented as means ± SEM. **P < .005; ***P < .0005. Ab, antibody; FEIBA, factor eight inhibitor bypassing activity.

Thrombin generation and fibrin network in hemophilia. (A) TF-induced (1 pM) thrombin generation in PRP from F8−/−Pros1+/+ and F8−/−Pros1−/− mice depicting TFPI-dependent PS activity. (B) APC-dependent PS activity in PRP and PFP from F8−/−Pros1+/+ and F8−/−Pros1−/− mice. (C) Representative scanning electron microscopy images from F8+/+Pros1+/+, F8−/−Pros1+/+, and F8−/−Pros1−/− fibrin structure and from F9+/+Pros1+/+, F9−/−Pros1+/+, and F9−/−Pros1−/− fibrin structure (Scale bars: 1 μm). (D-G) Thrombin generation triggered by low TF concentration (1 pM) in PFP (D-E) and PRP (F-G) from severe HA patients (FVIII < 1%) without (D,F) and with (E,G) a high titer of inhibitor. Measurements are presented as means ± SEM. **P < .005; ***P < .0005. Ab, antibody; FEIBA, factor eight inhibitor bypassing activity.

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