Figure 2.
![Figure 2. VWF multimer analysis of type 2B VWD cases. VWF multimer analysis (1% agarose gel) demonstrates the characteristic deficiency of high-molecular-weight multimers in 2 of the cases described with type 2B VWD. In each set of gel images, the patient plasma is compared with a normal plasma control (N). (A) The patient in case 1 (P) has loss of high- and some intermediate-weight VWF multimers. Affected multimer sizes are indicated by the bracket. (B) The patient in case 3 shows persistent deficiency of large- and some intermediate-weight VWF multimers on this VWF:Ag normalized multimer gel comparing a sample from her baseline (from an archival plasma sample) with samples during gestation (indicated in weeks [wks]).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/131/12/10.1182_blood-2017-06-742692/4/blood742692f2.jpeg?Expires=1724239640&Signature=ulegfj7XR9XngluerXKzYEEAEOAVDv6iOS~GLI8Xl-QOk~BGSchTRkFCWNA0u8n6gRbAFHY1Yrsi1kH7xD8Iqwm4jJ95zGuZea-n3kC0gGm5P7k5SSOIzW9E09y8gkdFSkXyZvvZbubRsGTqvZLC9JGsfH4LZccKvF8KJcdQFJ9PZKdpDSluKUlsW0kyfDbwy5pEEfqhfA~nRWSc9y6TC2lho8tidN3umxKfZrDnFmPEDLZ5gByGSM6urRUBAPYi9Mvmd1kozk-deU1wKWcflDluyqL0GmQHvWvXmoYgCgVlImoI~S6WQ2eYFFLIpuhwG30NRiIyROa5ZzHl-ZLzdQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
VWF multimer analysis of type 2B VWD cases. VWF multimer analysis (1% agarose gel) demonstrates the characteristic deficiency of high-molecular-weight multimers in 2 of the cases described with type 2B VWD. In each set of gel images, the patient plasma is compared with a normal plasma control (N). (A) The patient in case 1 (P) has loss of high- and some intermediate-weight VWF multimers. Affected multimer sizes are indicated by the bracket. (B) The patient in case 3 shows persistent deficiency of large- and some intermediate-weight VWF multimers on this VWF:Ag normalized multimer gel comparing a sample from her baseline (from an archival plasma sample) with samples during gestation (indicated in weeks [wks]).
