RS of patients with HCL in The Netherlands according to age at diagnosis and calendar period of diagnosis, 1989 to 2015. Relative survival rates (RSRs) are shown for the following age categories: <60 years (A), 60 to 69 years (B), and ≥70 years (C). The table presents the projected 5- and 10-year RSRs with 95% confidence intervals (CIs) according to age at diagnosis and calendar period of diagnosis. To illustrate the dynamics of RS, the OS in the patient cohort and the expected OS of an equivalent group from the general population, matched to the patients with respect to age, sex, and period, are plotted in supplemental Figure 2. Asterisk indicates P value for likelihood ratio test assessing linear trends from the period 1989 to 1993 to the period 2001 to 2015.