Illustration on the effect of gut microbiota on TLR2 signaling and VWF-mediated platelet deposition to the arterial injury site. Microbial patterns released by commensal microbiota augment VWF synthesis by triggering TLR2 signaling in the hepatic endothelium. In the absence of microbiota, reduced VWF plasma levels result in impaired VWF-integrin binding and reduced platelet deposition to the subendothelial matrix at the arterial injury site.