Characterization of the AdCre/BRAF^V600Elung. (A) H&E staining of lung sections from AdCre/BRAF^V600E mice. Low (top) and high (middle) magnification images focusing on epithelial tumor (papillary adenoma)-rich (left) and epithelial tumor-free (right) areas are indicated. Enlarged images for the boxed area in the middle panel are indicated at the bottom. Scale bars represent 0.5 mm (top) and 125 μm (middle). (B) PCR detection of the recombined BRAF^V600E (Lox-V600E) allele in sorted hematopoietic populations from the AdCre/BRAF^V600E lung. The recombined Lox-V600E allele was only faintly detected in CD45⁺CD11b^low-intCD11c⁺ cells (population 2), and was much weaker than the BRAF^WT (WT) allele. No recombination of the allele was detected in 2 other populations.