Peripheral blood and BM biopsy. (A) Peripheral blood smear (Wright stain, ×1000) and (B) BM core biopsy (Wright Giemsa, ×600) at the time of diagnosis of CLL. The neoplastic mature B-cells are small in size with clumped chromatin. (C) CD20 (immunoperoxidase, ×600) and (D) CD5 (immunoperoxidase, ×600) highlight the CLL cells. (E) BM aspirate (Wright Giemsa, ×1000) and (F) BM core biopsy (hematoxylin and eosin stain, ×600) at ALL diagnosis. The lymphoblasts are medium to large in size with fine chromatin, inconspicuous nucleoli, and scant basophilic cytoplasm with or without containing cytoplasmic vacuoles.