Transfer of Neu^ACEneutrophils into immunosuppressed mice increased resistance to MRSA infection. WT mice were made neutropenic with cyclophosphamide (230 mg per mouse, single IP dose). Mice were divided into 3 groups, and 1 day after drug injection, the mice were challenged subcutaneously with MRSA (3 × 106 CFU). Two days after drug injection, mice received 10⁷ neutrophils of IV purified from bone marrow of either WT or Neu^ACE mice. One group of mice received PBS only. (A) Skin lesion area and (B) bacterial counts in skin lesions (B) were measured 3 days after MRSA infection. *P ≤ .05, **P ≤ .005, ***P ≤ .0005.