Baseline methylation status of CpG loci in the FDFT1 gene region. There are 3 CpG probes located in this region on the Infinium HumanMethylation450 array. (A) Methylation status of the FDFT1 gene region in the peripheral blood of AML patients enrolled in the TACL trial at baseline. P = .0021 across all 3 CpGs, by Fisher’s exact test. (B) Methylation status of the FDFT1 gene region in BM or peripheral blood (as available) from patients enrolled in the D-ADE arm of the DACOGEN202 trial at baseline. P = .0022. PD, progressive disease.