CD27 expression on lymphoma cells prolongs survival. (A-D) Kaplan-Meier survival curves of BL/6 (A), RAG^−/− (B), RAGγc^−/− (C), and CD70^−/− (D) mice, injected IV with Q2A-CD27-trunc or Q2A-empty lymphoma cells. (E-G) Kaplan-Meier survival curve of 303 patients with Burkitt lymphoma and DLBCL in correlation with the expression of CD27 (CD27^hi n = 268, CD27^low n = 35) (E), CD56 (CD56^hi n = 201, CD56^low n = 102) (F), and NKG2D (NKG2D^hi n = 272, NKG2D^low = 31) (G). (H) Correlation analysis of expression of NK cell marker NKG2D and CD27 in lymphoma patients. Data are shown as mean ± SEM of 4 to 5 animals in each group (A-D) and representative of 2 experiments. Statistics: log-rank analysis (A-G). Spearman correlation test (H).