Figure 5.
![Figure 5. Genome-wide association for germline variants associated with clonal hematopoiesis detected by WGS-outlier status. (A) Manhattan plot of association [expressed as –log10(P)] with WGS-outlier status, determined using logistic regression. (B) Locus zoom of the signal in the TERT gene on chromosome 5. The location of the 8-bp indel rs34002450 (chr5:1280825) giving the strongest signal is indicated by a purple diamond. Other variants are plotted in colors corresponding to their r2 values relative to rs34002450, as indicated in the legend. Recombination rates, in cM/Mb and based on Icelandic data, are plotted as a red line. The lower panel shows the locations of RefSeq genes and the chromosomal position (GRCh38/hg38).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/130/6/10.1182_blood-2017-02-769869/4/blood769869f5.jpeg?Expires=1725190860&Signature=wX9qRLVXWAGSSJ8YJVQCD0BkS6iq2aum5KlhSdahqWtyOEUiWZE9JIwqcOma2CAWAXXaEIMr65VYdLySR6Rwi6y-8zmw~aFX1DdDwhYqrndn85XdC3QYdrHpUKC6Vipnb9cqJVWRH-YIYnsNlGkKQp8WDhDBlhTn39e33zoeickph4VYL37CB-irhVZvCAQZN5RxXiOx0vRM0ALsU2~4motQt54uu8OJ8BLIvsJpnxBq2mqsA7vRB1R7L9zeSwrgKb51cny4CSU1xREoeIvn16xmeLWxCNb6YaJ2XxkjT0NJ6Qnk7q3KH8doq9mfIwzRpinPO1Dy2iZr0iEakXZPCg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Genome-wide association for germline variants associated with clonal hematopoiesis detected by WGS-outlier status. (A) Manhattan plot of association [expressed as –log10(P)] with WGS-outlier status, determined using logistic regression. (B) Locus zoom of the signal in the TERT gene on chromosome 5. The location of the 8-bp indel rs34002450 (chr5:1280825) giving the strongest signal is indicated by a purple diamond. Other variants are plotted in colors corresponding to their r2 values relative to rs34002450, as indicated in the legend. Recombination rates, in cM/Mb and based on Icelandic data, are plotted as a red line. The lower panel shows the locations of RefSeq genes and the chromosomal position (GRCh38/hg38).
