Age distribution of clonal hematopoiesis detected by WGS-outlier status. (A) Histograms showing the number of mosaic somatic mutations per person stratified by their age at blood sampling (adjusted as described in the supplemental Data). The vertical line shows the cutoff at 20 mosaic somatic mutations (corresponding to the 99.5% quantile of the distribution for ages younger than 35 years) that was used to classify individuals as WGS-outliers. (B) Prevalence of clonal hematopoiesis and CD mutations stratified by age class. Lavender bar, the fraction of samples classified as WGS-outliers; red bar, the fraction of samples with detected CD mutations from the 18-gene candidate list18 ; green bar, the fraction of samples detected as outliers, using exon-restricted analysis; blue bar, combined fraction of samples detected with CD mutation or exon-restricted analysis. Error bars indicate 95% confidence intervals.
