VA-lip HSP47 resolve established skin fibrosis in chronic GVHD. Mice were transplanted as in Figure 1. VA-lip HSP47 were intravenously injected 3 times per week from day +21 to day +41 into allogeneic recipients. Representative images of MT staining (A) and skin pathological GVHD scores (B) on day +21. (C-E) The skin samples were harvested on day +42 after BMT. (C) Representative images of MT staining. Skin thickness (D) and amount of collagen deposit (E) on day +42 in the skin of syngeneic (n = 7), allogeneic (n = 14), and allogeneic recipients treated with VA-li pHSP47 (n = 11) from 2 independent experiments were combined and are shown as means ± SEM. Scale bar, 50 µm. *P < .05; **P < .01.