Treatment algorithm for first relapse of MM in fit patients. *Mostly if intolerant to bortezomib. B or Bort or V, bortezomib; C or Cy, cyclophosphamide; D, dexamethasone; Da, daratumumab; E, elotuzumab; I, ixazomib; K, carfilzomib; L or R, lenalidomide; P, prednisone; Pom, pomalidomide; T, thalidomide.