Downregulated genes and increased SNP frequencies in monosomy 7 cells. (A) Venn diagram of downregulated genes in patients 1 and 2 and patient 4 MEP. Patient 4 MEP cells were defined as cells that clustered to the MEP population from supplemental Figure 7D. Numbers in brackets indicate genes located on chromosome 7. (B) Downregulated genes in monosomy 7 CD34⁺ cells in patients 1 and 2 and patient 4 MEP (P < .05) were combined and subjected to network construction. Genes involved in different signaling pathway groups are highlighted in different border colors. Genes on chromosome 7 are highlighted in red. (C) The number of SNPs per cell in patient 4. CD38⁻, CD34⁺CD38⁻ cells; CD38⁺/HSC, CD34⁺CD38⁺ cells within the HSC/multilymphoid progenitor population (x location < 10 on MST); and CD38⁺/MEP, CD34⁺CD38⁺ cells within the MEP population (x location ≥ 10).