Figure 6.
ACF reduced CML development in vivo. CML mice were treated daily for 10 days with ACF or placebo and euthanized after 1 additional day. (A) Spleen weight; dotted line: non-CML mice. Data are mean ± S.D. of 8 mice per experimental variant; **P ≤ .01. (B) Hematoxylin-stained lung sections (original magnification ×40) from 2 representative mice per experimental variant (scale bar, 25 µm). (C) Total PB WBCs. Data are mean ± S.D. from 8 mice per experimental variant; **P ≤ .01. (D) Percentage of GFP+ (leukemic) or GFP− (nonleukemic) myeloid cells (Gr-1+) in PB. Plots show data from 1 representative mouse per experimental variant. Means ± S.D. from 8 mice per experimental variant are reported inside the plots.

ACF reduced CML development in vivo. CML mice were treated daily for 10 days with ACF or placebo and euthanized after 1 additional day. (A) Spleen weight; dotted line: non-CML mice. Data are mean ± S.D. of 8 mice per experimental variant; **P ≤ .01. (B) Hematoxylin-stained lung sections (original magnification ×40) from 2 representative mice per experimental variant (scale bar, 25 µm). (C) Total PB WBCs. Data are mean ± S.D. from 8 mice per experimental variant; **P ≤ .01. (D) Percentage of GFP+ (leukemic) or GFP (nonleukemic) myeloid cells (Gr-1+) in PB. Plots show data from 1 representative mouse per experimental variant. Means ± S.D. from 8 mice per experimental variant are reported inside the plots.

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