Time-course activation of coagulation, fibrinolysis, and complement pathways during Xa/PCPS vs E coli challenge. (A) TAT, (B) fibrinogen, (C) tissue plasminogen activator (t-PA), (D) plasmin-antiplasmin (PAP) complexes, (E) d-dimer, (F) C3b, (G) C5a, and (H) C5b-9 levels in baboon plasma following LD100 E coli (▪; n = 3) or FXa/PCPS infusion (●; n = 3).