Overall survival according to Mayo stage 2004. (A) In the low-dFLC cohort, median survival was not reached (stage I, N = 75), 96 months (stage II, N = 98), or 43 months (stage III, N = 30). (B) In the high-dFLC cohort, median survival was 89 months (stage I, N = 112), 38 months (stage II, N = 364), or 6.6 months (stage III, N = 390).