IgM antibodies, cytokines, and chemokines. (A) Individual serum IgM levels. Vertical dotted lines indicate start of leniolisib dosing. Normal values in healthy donors aged 16 to 19 years, 0.23 to 2.59 g/L; older than 19 years, 0.40 to 2.30 g/L.³⁷  (B) Soluble serum cytokines and chemokines. Vertical dotted lines indicate start of leniolisib dosing. Data are shown as mean values of 6 patients with SD. Normal values in healthy volunteers are shown as shaded areas.