Patients with low VWF have significant bleeding phenotypes. (A) ISTH BAT scores by sex, females, n = 112 (triangles, median = 8), and males, n = 14 (circles, median = 3). (B) Condensed MCMDM-1 VWD bleeding scores by sex. Black lines indicate median scores in females, n = 112 (triangles, median 5), and males, n = 14 (circles, median 0.5). (C) ISTH BAT scores studied in LoVIC subgroups with lowest plasma VWF levels in the range 30 to 39 IU/dL (females, triangles; males, circles) compared with patients with lowest VWF levels in the range 40 to 49 IU/dL (females, diamonds; males, squares). No significant difference was seen for either females (median 9 vs 7, P = .09, ns = not significant) or males (median 3 vs 3, P = .7). The upper limit of bleeding scores considered normal for each score is indicated by the green dotted line; median is shown by the black line.