Cytokine pattern associated with CAR T cells. CARs bind CD19 antigens, stimulating a cytotoxic response and proliferation. Among cytokines/chemokines elevated during CRS are several associated with activated T cells (IFN-γ, IL-6), macrophage activation or recruitment (IL-10, MCP-1), and inflammation (IL-6, IL-8). Professional illustration by Somersault18:24.