Relationship between vorinostat dose and response. Low doses are anti-inflammatory, whereas high doses of vorinostat are cytotoxic. IDO, indoleamine 2,3-dioxygenase; IL-1, interleukin-1; TNF, tumor necrosis factor; Tregs, regulatory T cells.
Relationship between vorinostat dose and response. Low doses are anti-inflammatory, whereas high doses of vorinostat are cytotoxic. IDO, indoleamine 2,3-dioxygenase; IL-1, interleukin-1; TNF, tumor necrosis factor; Tregs, regulatory T cells.
