VWF structural analyses pre- and postinfusion of BAX 930. (A) Representative sodium dodecyl sulfate-agarose gel pattern of pretreatment TTP plasma depicting UL, large, intermediate, and small VWF multimers. (B) The proportions of intermediate and large/UL multimers of plasma VWF were estimated from sodium dodecyl sulfate-agarose gels at various times before and after infusion of 40 U/kg BAX 930. The observed concentration of large and UL multimers tended to decrease in all treated patients in the first 12 hours before gradually returning to preinfusion levels. (C) Time course of the 176-kDa ADAMTS-13 VWF cleavage product after administration of 5, 20, and 40 U/kg BAX 930. High levels of detectable VWF cleavage products are apparent just after dosing, which gradually return to preinfusion levels in a dose-related manner.