Schematic overview variants in the FCGR2C gene that influence its expression. Because of a premature stop codon, the FCGR2C gene is a nonexpressed pseudogene in FCGR2C-stop individuals. A SNP in exon 3 can lead to an open reading frame (ORF), which results in expression of the gene (FCGR2C-ORF variant). An additional splice site mutation near exon 7 can generate another stop codon, which in turn results in no expression of FcγRIIc.^51,72  This last variant is the FCGR2C.nc-ORF polymorphism. The FCGR2C.nc-ORF variant is a combination of the exon 3 SNP and the splice site mutation at exon 7. SNPs are indicated with orange boxes. STOP, stop codon.