The landscape of cancer-promoting amino acid alterations in putative driver genes in cutaneous T-cell lymphoma. Genomic analysis of 220 CTCLs implicates mutations in 55 genes in CTCL pathogenesis. Genes with protein-altering amino acid alterations are shown here. Damaging mutations include frameshift mutations, splice-site mutations, and truncating nonsense mutations. For clarity, JAK2 is depicted without any mark of point mutation, as it is subject to recurrent amplifications, but no point mutations.