Activation of a subset of hypomethylated TSS distal DMCs in CN-AML patients. (A) Hierarchical clustering of hypomethylated TSS distal DMCs for H3K27ac revealed 2 distinct clusters showing either no activation (n = 3282) or a gain of histone acetylation (n = 956) in AML patients. (B) TSS distal DMCs overlapping with enhancers showing increased H3K27ac in AML. (C) H3K27ac at TSS distal hypomethylated DMCs not overlapping H2A.Z ChIP-seq peaks (green) or overlapping H2A.Z peaks (red).