Plasmin and MMP-9 inhibition reduces the production of several inflammatory cytokines/chemokines in MAS mice. (A-C) Plasma TNF-α levels were determined at indicated time points in samples from CpG/DG-injected (A), Plg^+/+ and Plg^−/− (B), and Mmp9^+/+ and Mmp9^−/− (C) mice treated with PBS or YO-2 (n = 3-6 per group). (D-F) Plasma Fas-L (D), CCL2 (E), and IFN-γ (F) levels were determined at indicated time points in samples from CpG/DG-injected mice treated with PBS or YO-2 (n = 3-6 per group). Data represent mean ± SEM. *P < .05, **P < .01, ***P < .001, using 1-way ANOVA with the Tukey posttest or the unpaired, 2-tailed Student t test for significance. ND, not detected.