Genes involved in epigenetic regulation and leukemic transformation. The mechanisms by which the genes involved in the epigenetic regulation described in Table 1 lead to modifications in gene regulation are detailed. Some genes involved in leukemic transformation (N-Ras pathway and transcription factors such as p53, RUNX1) are also described. MEK, MAPK/ERK-kinase; RAF, rapidly accelerated fibrosarcoma; SOS, Son of Sevenless; TF, transcription factor. Professional illustration by Somersault18:24.