ZEB2 directly represses genes involved in myeloid differentiation. (A) Motifs with the CACCTG sequence are enriched in the promoters of ZEB2KD^up genes based on CisFinder analysis. (B) Enrichment of CTCCTG sequence in different genomic regions of ZEB2KD^up genes as analyzed by the oligo-diff tool of RSAT. (C) GSEA shows that ZEB2KD^up genes with CACCTG sequence in their promoters are highly expressed in epithelial cells and downregulated during EMT triggered by E-cadherin knockdown or TWIST/SNAIL/TGF-β1 expression. (D) ZEB2 coimmunoprecipitate with CtBP1, LSD1, HDAC1, and EHMT1 in THP-1 cells. TSS, transcription start site; FDR, false discovery rate; NES, normalized enrichment score; IP, immunoprecipitate; SN, supernatant.