Depletion of human CLL-1+ 2xBAC-Tg mouse cells from blood and bone marrow after single IV dose administration of 0.5 mg/kg CLL-1 TDB. (A) CLL1/CD3VH, (B) CLL1/CD3H, and (C) CLL1/CD3L. Percent of hCLL-1⁺ cells were derived from the average naïve untreated mice hCLL-1⁺ cells; blood (n = 39), bone marrow and spleen (n = 4). Upregulation of CD69 on CD8⁺ and CD4⁺ T cells by (D) CLL1/CD3VH, (E) CLL1/CD3H, and (F) CLL1/CD3L. Time points are terminal bleeds. The mean and standard deviation are represented by horizontal and vertical lines, respectively.