Model of AHR activity in human developmental hematopoiesis. AHR inhibition mediated by SR-1 (blue arrow) enhances the differentiation of both endothelial cells (ECs) and CD34⁺ hematopoietic progenitor cells. AHR hyperactivation mediated by TCDD (orange arrow) reciprocally acts to attenuate both ECs and CD34⁺ hematopoietic progenitor cells. Once CD34⁺ has been differentiated, AHR inhibition deters further differentiation into CD34⁻ terminally matured hematopoietic cells, whereas AHR hyperactivation supports this process. Upon production of NKP cells, AHR inhibition promotes cNK cell differentiation (cNK), whereas AHR hyperactivation promotes ILC3 differentiation.