Histochemical analysis of intrathrombotic collagen content by Picrosirius Red staining at day 12 after vena cava ligation; original magnification ×100. Representative images from 4 to 5 independent mice of each genotype are shown. The intrathrombus collagen area was quantitated as a measure of fibrosis, as described in “Methods” in the article by Mukhopadhyay et al. All values represent the mean ± SEM (n = 4-5). *P < .05, p53 Mp53^+/+ vs Mp53^−/−. See Figure 5D in the article by Mukhopadhyay et al that begins on page 3245.