Figure 5.
![Binding of 2,3-DPG to Hb. (A-B) 2,3-DPG binds in the cleft between the β (yellow) subunits of the T quaternary structure. (C) Reduction of 2,3-DPG concentration shifts the quaternary equilibrium toward R to produce a left shift in the binding curve and increases the solubility (the concentration of Hb in the solution phase [Figures 3B and 4B, left]). Both factors decrease sickling.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/129/20/10.1182_blood-2017-02-765891/4/blood765891f5.jpeg?Expires=1720280119&Signature=GLg7ZPKJk04Le7V174wM5LShak07c3ZVlVxg9UHn47qXEaHETFbI3Frk08~Hm8Qxzkdi-iTLbb5AiXFiBL1P96tnRYRrAMGrzB~483SCILg1c4hhM10uubadrF37i52s7aKdY7~Uh2G3prCc40c4ZoS9p2nv91ILP0CZk0KO59e91uPDtBju8UzP4~pD81bXCWoCoBi4AgV2d9XP~3R6M5v5QNkf6kxdYWK7qrgBlo7LgD2vESEBOrl2kmePnvXXriIgF1RW524ObRD7BTeEEnDLYnLmod9j6f46TkZvggtewWtiIy7HuITYLW0WW02Prv2gCMnnmm6PrdsxdcyO-g__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Binding of 2,3-DPG to Hb. (A-B) 2,3-DPG binds in the cleft between the β (yellow) subunits of the T quaternary structure. (C) Reduction of 2,3-DPG concentration shifts the quaternary equilibrium toward R to produce a left shift in the binding curve and increases the solubility (the concentration of Hb in the solution phase [Figures 3B and 4B, left]). Both factors decrease sickling.
