Spectrum and correlation of MYC and BCL2 genetic alterations in DLBCL. (A) Statistically significant (q < 0.01) positive (red) and negative (green) correlations among MYC/BCL2 genetic alterations and MYC/BCL2 protein expression in the entire DLBCL cohort (left), ABC-DLBCL (center), and GCB-DLBCL (right), detected by pairwise calculations of Fisher’s exact test. The size and color for each circle indicates the level of significance, as expressed by the q-value and correlation, respectively. (B) The distribution and interaction of MYC/BCL2 genetic alterations, according to COO subtypes.