Figure 7.
Figure 7. Working model of p19INK4d function during human terminal erythroid differentiation. The blue arrow denotes a “decreased” expression, whereas the red arrow denotes an “increased” expression. p19INK4d knockdown increases PEBP1 expression and impairs the p-ERK-HSP70-GATA1 pathway, which delays human terminal erythroid differentiation and leads to generation of abnormal nucleus.

Working model of p19INK4dfunction during human terminal erythroid differentiation. The blue arrow denotes a “decreased” expression, whereas the red arrow denotes an “increased” expression. p19INK4d knockdown increases PEBP1 expression and impairs the p-ERK-HSP70-GATA1 pathway, which delays human terminal erythroid differentiation and leads to generation of abnormal nucleus.

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