Crebbp deletion promotes B-cell lymphoma in tandem with Bcl2 overexpression. (A) A Kaplan-Meier plot shows the lymphoma-specific survival of 6 transgenic strains. It can be seen that deletion of 1 or both alleles of Crebbp leads to the development of lymphoma at a late time point in some mice, that the penetrance is increased and the latency is decreased with the addition of the EµBcl2 transgene. (B) An example of spleens and lymph nodes from Cbp^Δ/ΔxEµBcl2 mice that became ill, showing splenomegaly and lymphadenopathy that is indicative of lymphoma. (C) Hematoxylin and eosin staining from representative spleen and lymph node samples of age-matched tumor-free Cbp^WT/F and tumor-bearing Cbp^Δ/ΔxEuBcl2 mice. The B-cell lymphomas can be seen to be associated with a diffuse spread of centroblasts, with loss of normal architecture. Pathology review determined this specimen to be most similar to DLBCL histology.