Effects of RN-1 treatment on additional hematologic parameters. (A) Changes in hemoglobin (solid red squares, dashed red line), fetal hemoglobin (blue circles, dotted blue line), absolute reticulocytes (purple triangles, solid purple line), and F retics (open green squares, solid green line) between days 148 and 190, coinciding with an incident of acute bleeding due to accidental laceration of the perineal swelling in PA8698. (B) Mean corpuscular volume (MCV), (C) neutrophils, (D) platelets (PLT), and (E) monocytes during days of treatment: PA8695 (solid red symbols, solid red line); PA8698 (open blue symbols, dashed blue line). (F) CD62 expression (mean fluorescence intensity [MFI]) on surface of platelets following addition of thrombin: untreated controls (red bar); PA8695 during treatment phase (blue bar); PA8698 during treatment phase (green bar); PA8695 1 week following cessation of RN-1 treatment (purple bar); PA8698 1 week following cessation of RN-1 treatment (orange bar). ANC, absolute neutrophil count.