Long-term RN-1 treatment increases F retics, F cells, and HbF. (A) F retics, (B) F cells, (C) HbF, (D) globin chain synthesis in peripheral blood reticulocytes, (E) hemoglobin (HGB) levels, and (F) absolute (Abs) reticulocyte counts during days of treatment: PA8695 (solid red symbols, solid red line); PA8698 (open symbols, dotted line).