Forest plot demonstrating the association of the cumulative viral load AUC with overall mortality from adjusted Cox models. (A) Models of the association of the cumulative viral load AUC with overall mortality in the entire cohort and among day-30 survivors with adjustment for immune reconstitution parameters. (B) Models that considered the effect of the cumulative viral load AUC within strata of acute GVHD to account for effect modification. In all models, viral detection was included as a time-dependent variable for overall mortality by day 100 and a time-invariant variable for overall mortality between day 101 and day 365 (because virus testing stopped at day 100). ^aAdjusted for age, HCT comorbidity index, underlying disease risk, conditioning regimen intensity, and acute GVHD (time dependent), and cumulative steroid dose AUC. ^bAdjusted for age, HCT comorbidity index, underlying disease risk, conditioning regimen intensity, and acute GVHD (time dependent), day 30 neutrophil engraftment, day 30 ALC < 200 cells/mm³, day 30 AMC < 300 cells/mm³, and cumulative steroid dose AUC. ^cAdjusted for age, HCT comorbidity index, conditioning regimen intensity, and underlying disease risk.