CLEC-2 exacerbates DVT in mice. (A) Clec1b^fl/fl × Rosa26^+/creERT2 (n = 10) and their Clec1b^fl/fl littermates (n = 9) after 2 weeks of tamoxifen diet followed by 4 weeks of normal diet or (B) Clec1b^fl/fl Pf4-Cre mice (n = 13) and control littermates (n = 11) were subjected to IVC stenosis for 48 hours. Some of the Clec1b^fl/fl Pf4-Cre mice were transfused with 8 × 10⁸ WT platelets prior to surgery. (i-iii) Thrombus weight, thrombus length, and thrombosis prevalence, respectively. Lines in dot plots represent median. Note restoration of thrombosis after transfusion of WT platelets.